It seems like a no-brainer. Make uranium burn stronger, hotter and longer in nuclear reactors, and you'll need less fuel, and there'll be less waste to deal with when it has been exhausted.
For decades, nuclear operators have done just that, but emerging safety and waste-disposal issues are raising questions about this approach. The latest high-efficiency fuel may prove to be unstable in an emergency, and so poses a greater risk of leakage of radioactive material into the environment. What's more, the waste fuel is more radioactive, meaning it could prove even more difficult than existing waste to store in underground repositories.